Sunday, 22 October, 2017

Dubochet, Frank, Henderson win Nobel Chemistry Prize for work in electron microscopy

LIVE Sweden's Nobel Prize in Chemistry 2017 Nobel chemistry prize awarded for molecular machines which repair damaged DNA
Derrick Tucker | 05 October, 2017, 00:52

Thanks to their team's new "cool method", involving electron beams to photograph bits of cells, "researchers can now routinely produce three-dimensional structures of biomolecules", the Nobel chemistry committee said. "A picture truly is worth a thousand words, and the laureates' discoveries are invaluable to our understanding of life and the development of new therapeutics to improve people's lives and the health of our planet".

"We are facing a revolution in biochemistry", said Nobel Committee Chairman Sara Snogerup Linseduring the announcement, according to CNN.

Potential payoffs include help in developing medicines and industrial chemicals, she said. In that way, the molecule retained its natural shape. Cryo-EM uses frozen samples, gentler electron beams and sophisticated image processing to overcome these problems.

Now, with the development of cryo-electron microscopy, researchers can freeze biomolecules mid-movement and observe how they act - and interact.

Speaking to journalists over a telephone line, Prof Frank said the practical uses for the technique were "immense".

Frank was born in Germany in 1940 and is now a professor at Columbia University in NY.

75-year-old Jacques Dubochet, was born in Switzerland, and is now a honorary professor of biophysics the Universite Lausanne.

Kim Jong Nam murder: pair plead not guilty
Prosecutors at Malaysia's High Court were seeking to establish the basic facts regarding Kim Jong Nam's death on February 13 . Personalities north Korean with a party related to the case have fled to Malaysia immediately after the murder.

Longtime NHL Broadcaster Dave Strader Passes at 62
In addition to his work in hockey, Strader also worked for the WNBA, the NBA D-League, college basketball and the Olympics. He was limited to calling five games with the Dallas Stars , the organization Strader was with the last two seasons.

Test wins for Sri Lanka and South Africa
And eventually Sri Lanka , taking full advantage of winning the toss and batting first, came out as a slightly better side. Pakistan are 5/4 with Sky Bet for victory , Sri Lanka can be backed at 4/1 and the draw is on offer at 6/5.

Richard Henderson of the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK, found a way to protect biomolecules by coating their surface with a glucose solution that stopped it from drying out in the vacuum.

Initial reactions from the academic community of chemists have been positive. He used his algorithms to generate images of the ribosome - a massive structure made of several proteins and RNA strands, which is responsible for translating RNA into protein inside cells. That, he adds, could aid the design of drugs to tackle the disease.

The prize is awarded by the Royal Swedish Academy of Sciences.

The literature victor will be named Thursday and the peace prize will be announced Friday.

Depiction of Zika virus cryo-EM structureWIKIMEDIA, STARLESSLast year, Henderson won the Royal Society's Copley Medal, the world's oldest scientific prize, for his work on imaging techniques.

Four years earlier, the 1982 Chemistry Nobel had gone to Aaron Klug "for his development of crystallographic electron microscopy and his structural elucidation of biologically important nucleic acid-protein complexes".

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